Journal: Neuroscience Bulletin
Article Title: Ventral Hippocampal CA1 Pyramidal Neurons Encode Nociceptive Information
doi: 10.1007/s12264-023-01086-x
Figure Lengend Snippet: Optogenetic inhibition of vCA1 pyramidal neurons induces mechanical allodynia in naïve rats. A Schematic of optogenetic virus injection and optical fiber implantation in the vCA1. B Representative confocal image of virus expression and optical fiber location in the vCA1. C Inhibition of vCA1 pyramidal neurons induces mechanical allodynia. n = 10 per group. *** P < 0.001, two-way ANOVA with Bonferroni’s post hoc test. D Representative movement tracks in a 10-min period during RTPP from mCherry (left) and NpHR (right) groups. The yellow areas indicate the light stimulation side. E Optogenetic inhibition decreases the time spent on the stimulation side in the NpHR group. n = 10 per group. * P < 0.05, unpaired t -test.
Article Snippet: Naïve Bayes classifiers in the MATLAB programming environment (fitcnb) were applied to test the specificity of the vCA1 neural code in response to various stimuli [ ].
Techniques: Inhibition, Virus, Injection, Expressing